(R,R)-(+)-Hydrobenzoin Manufacturer CAS No.: 52340-78-0

Certificate of Analysis:

Item	Index	Test Result
Appearance	white to off white solid	white to off white solid
Identification (H-NMR)	positive	conforms
Purity (HPLC)	>97%	98.00%
Chiral Purity(e.e.%)	>97%	99.80%
Conclusion		Approved

(R,R)-(+)-Hydrobenzoin also named (R,R)-(+)-1,2-Diphenyl-1,2-ethanediol, Cas No.: 52340-78-0, molecular weight: 214.26 g/mol is a specific stereoisomer of hydrobenzoin, a diol derived from benzoin. It is a compound with two hydroxyl groups (-OH) attached to a two-carbon chain, which is itself substituted with two phenyl groups (C6H5-). Because the carbon atoms bearing the hydroxyl groups (C1 and C2) are chiral centers, hydrobenzoin exists in several stereoisomeric forms.

These forms include:

(R,R)-Hydrobenzoin Cas No.: 52340-78-0: Both chiral centers are in the R configuration.

(S,S)-Hydrobenzoin Cas No.: 2325-10-2: Both chiral centers are in the S configuration.

(R,S)-Hydrobenzoin Cas No.: 655-48-1: One chiral center is R, and the other is S (this is the meso form and is optically inactive).

Characteristics of (R,R)-(+)-Hydrobenzoin Cas No.: 52340-78-0:

Optical Activity: The (+) denotes that (R,R)-Hydrobenzoin is the enantiomer that rotates plane-polarized light to the right (dextrorotatory).

Purity: In this form, the compound is enantiomerically pure, meaning it predominantly consists of the (R,R) enantiomer without significant amounts of the (S,S) enantiomer or the meso form.

Synthesis:

(R,R)-(+)-Hydrobenzoin can be synthesized through the reduction of benzoin using various reducing agents such as sodium borohydride (NaBH4) or catalytic hydrogenation.

Physical Properties:

Appearance: (R,R)-(+)-Hydrobenzoin is typically a white to off-white crystalline solid.

Solubility: It is relatively soluble in organic solvents such as ethanol and acetone.

Applications:

Asymmetric Synthesis: We can use (R,R)-(+)-Hydrobenzoin as a chiral building block in the synthesis of other complex molecules.

Catalysis: Serves as a ligand in asymmetric catalytic reactions.

Resolution of Racemic Mixtures: Employed in resolving racemic mixtures into their enantiomers due to its chiral properties.

Safety:

Like many organic compounds, we should handle (R,R)-(+)-Hydrobenzoin with care, adhering to safety protocols such as wearing gloves and eye protection. We also need to store it in a cool, dry place and kept away from incompatible substances.