4-Iodo-2,2-dimethyl-tetrahydro-pyran Manufacturer CAS No.: 882687-80-1

Certificate of Analysis (CAS No.: 882687-80-1):

Item	Index	Test Result
Appearance	colorless transparent liquid	colorless transparent liquid
Identification (H-NMR)	positive	conforms
Purity (HPLC)	>98%	98.5%
Water content	<0.5%	0.10%
Conclusion		Approved

What is 4-Iodo-2,2-dimethyl-tetrahydro-pyran Cas No.: 882687-80-1 ?

4-Iodo-2,2-dimethyl-tetrahydro-pyran CAS No.: 882687-80-1 is an organic compound that plays a significant role in synthetic chemistry, especially in the field of medicinal and organic synthesis.

Chemical Structure of Cas No.: 882687-80-1

1. Tetrahydro-pyran (THP): Tetrahydro-pyran is a six-membered saturated (fully hydrogenated) oxygen-containing heterocycle. We often use it as a protective group for alcohols in organic synthesis.
2. 2,2-Dimethyl: This indicates that there are two methyl groups attached to the second carbon of the tetrahydro-pyran ring. These methyl groups influence the steric and electronic properties of the compound.
3. 4-Iodo: An iodine atom attache to the fourth carbon of the tetrahydro-pyran ring. The presence of the iodine atom makes this compound useful for various chemical transformations.

Main Application

1. Synthetic Intermediate: We often use 4-Iodo-2,2-dimethyl-tetrahydro-pyran as an intermediate in organic synthesis. The iodine atom makes it a versatile starting material for various cross-coupling reactions, such as Suzuki, Sonogashira, or Stille couplings, which are key methods for forming carbon-carbon bonds in the synthesis of complex organic molecules.

2. Pharmaceutical Synthesis: The compound is valuable in the synthesis of pharmaceutical agents. We modify its structure to introduce different functional groups or to build more complex molecular frameworks, which are essential in drug development.

3. Building Block in Natural Product Synthesis: The tetrahydropyran ring is a common structural motif in many natural products. We use 4-Iodo-2,2-dimethyl-tetrahydro-pyran to construct these types of rings in the synthesis of natural product analogs or derivatives.

4. Protecting Group for Alcohols: While not its primary role, the tetrahydropyran ring structure can act as a protecting group for alcohols in synthetic pathways. This usage leverages the stability of the ring structure to protect alcohols from reacting under certain conditions.

5. Source of Iodine for Functional Group Transformation: We can use iodine atom in 4-Iodo-2,2-dimethyl-tetrahydro-pyran to introduce various functional groups through nucleophilic substitution or elimination reactions, facilitating the exploration of new chemical entities in research.

Summary

4-Iodo-2,2-dimethyl-tetrahydro-pyran is a versatile compound in organic synthesis due to its unique structure, which allows it to participate in various chemical reactions. Its main applications are as a synthetic intermediate and a building block in pharmaceutical and natural product synthesis, where it aids in constructing complex molecular architectures.