4-Chloro-5H-Pyrrolo[3,2-D] Pyrimidine Manufacturer CAS No.: 84905-80-6

What is 4-Chloro-5H-Pyrrolo[3,2-D] Pyrimidine CAS No.: 84905-80-6

4-Chloro-5H-Pyrrolo[3,2-D] Pyrimidine CAS No.: 84905-80-6 is an aromatic heterocyclic compound featuring a fused ring system combining pyrrole and pyrimidine structures. The presence of a chlorine atom at the 4-position is a key feature, impacting its chemical reactivity and application.

Properties

1. Aromaticity:
   • The fused ring system is aromatic, providing stability and specific electronic properties.
2. Chlorine Reactivity:
   • The chlorine substituent is reactive and can undergo various substitution reactions, making the compound a useful intermediate in organic synthesis.
3. Solubility:
   • Soluble in organic solvents, aiding its use in various chemical reactions and applications.

Main Applications

We can use 4-Chloro-5H-Pyrrolo[3,2-D] Pyrimidine CAS No.: 84905-80-6 in the fields of medicinal chemistry and drug discovery, where it serves as a building block for synthesizing biologically active compounds. Its applications include:

1. Pharmaceutical Synthesis:
   • Kinase Inhibitors: This compound is a key intermediate in the synthesis of kinase inhibitors. Kinases are enzymes that play crucial roles in signaling pathways, and their inhibition is a strategy for treating cancers and other diseases.
   • Antiviral Agents: Structural analogs derived from this compound are explored for their potential to inhibit viral enzymes, making them candidates for antiviral drug development.
2. Heterocyclic Chemistry:
   • As a heterocyclic scaffold, we use 4-Chloro-5H-Pyrrolo[3,2-D] Pyrimidine to create a variety of substituted pyrrolopyrimidines, which are valuable in designing molecules with desired biological activities.
3. Research and Development:
   • Widely used in academic and industrial research for the development of new chemical entities (NCEs) with potential therapeutic applications.
   • We modify its structure to explore structure-activity relationships (SAR) in drug discovery programs.
4. Intermediate in Synthesis:
   • Acts as a versatile intermediate in organic synthesis, we can replace its chlorine atom with various functional groups through nucleophilic substitution reactions.

Advantages in Drug Development

1. Diverse Reactivity:
   • The presence of the chlorine atom allows for facile modifications, enabling the synthesis of diverse derivatives for biological testing.
   • The fused heterocyclic core can engage in various interactions with biological targets.
2. Biological Relevance:
   • We find the pyrrolo[3,2-D]pyrimidine scaffold in many biologically active molecules, making this compound a valuable starting point in drug design.
3. Structural Versatility:
   • The aromatic and heterocyclic nature of the molecule provides a stable and versatile framework for designing compounds with specific properties and activities.

Examples of Applications in Medicinal Chemistry

1. Cancer Treatment:
   • Derivatives of this compound have been explored for their potential as kinase inhibitors, targeting enzymes involved in cancer cell proliferation and survival.
2. Antiviral Research:
   • Modified structures based on 4-Chloro-5H-Pyrrolo[3,2-D] Pyrimidine have been investigated for their ability to inhibit viral replication by targeting viral enzymes.
3. Neuroprotective Agents:
   • Research into neurodegenerative diseases often involves compounds that can modulate signaling pathways in the brain, where pyrrolo[3,2-D]pyrimidine derivatives are considered for their therapeutic potential.

Conclusion

4-Chloro-5H-Pyrrolo[3,2-D] Pyrimidine is a versatile and valuable compound in the realm of organic and medicinal chemistry. Its utility as a precursor for biologically active molecules and its role in the synthesis of pharmaceutical compounds underscore its significance in drug discovery and development. The unique combination of a fused heterocyclic ring system and a reactive chlorine substituent makes it an important scaffold for designing new therapeutic agents.