1-(2-(trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylic acid CAS No.: 1260855-51-3

What is 1-(2-(Trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylic Acid?

1-(2-(Trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylic acid CAS No.: 1260855-51-3 is a chemical compound featuring a pyrazole ring substituted with a carboxylic acid group and a trifluoromethyl-phenyl group.

Chemical Structure and Properties

• Chemical Formula: C11H7F3N2O2
• IUPAC Name: 1-[2-(Trifluoromethyl)phenyl]-1H-pyrazole-4-carboxylic acid
• Molecular Structure:
  • The compound consists of a pyrazole ring, a five-membered ring containing two nitrogen atoms.
  • A carboxylic acid group (-COOH) is attached to the 4th position of the pyrazole ring.
  • A phenyl group substituted with a trifluoromethyl group (-CF₃) is attached to the 1st position of the pyrazole ring.

This combination of functional groups and the presence of a trifluoromethyl group contributes to the compound’s reactivity and its specific application in various fields.

Main Application

1. Pharmaceutical Industry:
   • Drug Design and Synthesis: The pyrazole ring system is a significant structural motif in medicinal chemistry. The trifluoromethyl group known for enhancing the pharmacokinetic properties of drugs, such as their metabolic stability and bioavailability.
   • Anti-inflammatory Agents: Researchers have used compounds with similar structures for their potential anti-inflammatory activity. The trifluoromethyl-phenyl group and carboxylic acid functionalities contribute to the binding affinity and activity of these compounds against target enzymes or receptors in the inflammatory pathways.
2. Chemical Research and Development:
   • Synthetic Intermediate: The compound can serve as an intermediate in the synthesis of more complex molecules. It including pharmaceuticals, agrochemicals, and other biologically active compounds.
   • Building Block: Its specific functional groups (pyrazole ring, carboxylic acid, trifluoromethyl group) make it a versatile building block for constructing novel chemical entities in research settings.
3. Agrochemicals:
   • Herbicides and Pesticides: Researchers have used similar pyrazole derivatives in the development of herbicides and pesticides.  Because of their ability to interact with biological targets in plants and pests, leading to effective control measures.
4. Material Science:
   • Specialty Chemicals: The trifluoromethyl group imparts unique chemical and physical properties to the molecule, and makes it useful in designing materials with specific characteristics, such as improved thermal stability or altered surface properties.

Summary

1-(2-(Trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylic acid is a compound with significant potential in pharmaceuticals, agrochemicals, and chemical research. Its structural features, including the pyrazole ring and the trifluoromethyl group, make it valuable for developing drugs with enhanced pharmacokinetic profiles and for synthesizing new chemical entities in various fields.