VIGABATRIN Manufacturer CAS No.: 60643-86-9

What is VIGABATRIN Cas No.: 60643-86-9 ?

Vigabatrin is an organic compound that serves as an important molecule in both pharmaceutical and research applications.

Chemical and Structural Information:

• Chemical Name: 4-Amino-5-hexenoic acid
• Molecular Formula: C₆H₁₁NO₂
• Structure: It consists of a six-carbon chain with a carboxylic acid group (–COOH) at one end, an amino group (–NH₂) on the fourth carbon, and a vinyl group (–CH=CH₂) on the fifth carbon.

Main Application:

Pharmaceutical Use:

The primary application of 4-amino-5-hexenoic acid is as the active ingredient in the anticonvulsant drug Vigabatrin.

1. Treatment of Epilepsy:
   • Refractory Complex Partial Seizures: Researchers use Vigabatrin as an adjunctive therapy for patients whose seizures are not adequately controlled with other medications.
   • Infantile Spasms: It is approved as a first-line treatment for infantile spasms (West syndrome), particularly in infants who have not responded to other treatments. This condition is characterized by a specific type of seizure seen in young children​.
2. Mechanism of Action:
   • GABA Transaminase Inhibition: 4-Amino-5-hexenoic acid irreversibly inhibits the enzyme GABA transaminase, which breaks down gamma-aminobutyric acid (GABA) in the brain. By inhibiting this enzyme, the compound increases the levels of GABA, an inhibitory neurotransmitter, leading to enhanced neuronal inhibition and a reduction in seizure activity​​.
3. Neurological Research:
   • Due to its effects on GABA metabolism, we also can use 4-amino-5-hexenoic acid in neuroscience research to study the role of GABA in various neurological and psychiatric disorders. This research can help in understanding and developing treatments for conditions such as epilepsy, anxiety, and depression​​.

Additional Applications:

While its primary application is in medicine, 4-amino-5-hexenoic acid can be of interest in other fields such as:

• Biochemical Research: Exploring the mechanisms of neurotransmission and enzyme inhibition.
• Drug Development: As a template or starting point for synthesizing new compounds with potential therapeutic benefits.

Safety and Usage:

When used as Vigabatrin, 4-amino-5-hexenoic acid requires careful monitoring due to potential side effects, most notably the risk of permanent vision loss. This necessitates regular eye exams during treatment​.