1,2-di-tert-butyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate Manufacturer CAS No.: 1260591-66-9

What is 1,2-di-tert-Butyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate Cas No.: 1260591-66-9 ?

1,2-di-tert-Butyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate Cas No.: 1260591-66-9 is a specialized organic compound often used as an intermediate in chemical synthesis. It features a pyrrolidine ring, which is a key component in many biologically active molecules. The compound’s specific configuration and protective groups make it valuable in organic synthesis, particularly in the pharmaceutical industry.

Main Applications:

1. Pharmaceutical Synthesis:
   • Intermediate in Drug Development: We mainly use this compound as an intermediate in the synthesis of pharmaceuticals. Its structure is conducive to the formation of complex drug molecules, especially those requiring a chiral center.
   • Prodrug Design:  We can hydrolyze the tert-butyl esters to yield active drug forms, making the compound useful in the creation of prodrugs, which are inactive precursors that convert into active drugs in the body.
2. Protective Groups in Organic Synthesis:
   • Temporary Protection: The tert-butyl groups act as protecting groups for carboxylic acids during multi-step synthesis. They prevent undesired reactions at the carboxylate sites, we can selectively remove it under mild acidic conditions to reveal the carboxylic acids for further functionalization.
   • Lactam Synthesis: Researchers can use it as a precursor for various functionalized pyrrolidine derivatives. Its lactam (cyclic amide) structure is useful in the synthesis of other heterocyclic compounds.
3. Asymmetric Synthesis:
   • Chiral Building Block: The chiral nature of the compound makes it valuable in the synthesis of enantiomerically pure substances. This is crucial in the pharmaceutical industry, where the chirality of a drug can significantly influence its efficacy and safety.
   • Chiral Catalysts and Ligands: We can use it to synthesize chiral catalysts and ligands for asymmetric catalysis, facilitating the production of enantiomerically enriched compounds.
4. Research and Development:
   • Chemical Research: Researchers utilize this compound to explore new synthetic methodologies and to develop novel organic compounds with potential applications in various fields.
   • Structure-Activity Relationship Studies: The compound is studied to understand the relationship between its chemical structure and its biological activity, aiding in the design of more effective and selective drugs.

Safety and Handling:

As with many specialized chemical intermediates, we should handle this compound with care in a controlled laboratory environment. It is not intended for direct human or animal use. We should take proper safety equipment and protocols to avoid potential risks.